S-Stem Scholar Anthony Luna's Blog

The three different species of bacteria: - Firmicutes - Clostridia - Clostridiales Ecosystem details: Digestive system -> Large intestine -> Fecal Transcription factor, CsoR.  Motif - Inverted repeat  G/C content - 69.23% Regulatory mode - Activation 0%, Repression 100%, Dual 0%, Not specified 0%. TF conformation - Monomer 0%, Dimer 0%, Tetramer 100%, Other 0%, Not specified 0%. Binding site type - Motif-associated 1, Variable-motif-associated 0, Non-motif-associated 0.  The specific type of gene regulation this transcription factor is involved in I couldn't determine. However, I'm inclined to say, TTHA.

P04745-Alpha-amylase 1 Uniprot ID: AMY1_HUMAN Protein: Alpha-amylase 1 Gene: AMY1A Diseases associated with alpha-amylase: None to be noted. Catalytic activity: Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units. Cofactor: Calcium ion (Ca2+) and Chloride ion (Cl-) Alpha-amylase was found to be rather mildly expressed exclusively in the pancreas. No other organs/regions could be noted.  Some aspects of alpha-amylase I am curious about are, one, why is there such little data about it? Two, why would it be expressed only in the pancreas and not somewhere along the digestive tract?  One project idea I have in mind is further investigating where else alpha-amylase could possibly be expressed, and discovering why it is expressed higher in one region than another. 

The top three results for the Gene-Disease Associations for my protein were the following: -   Evidence for AMY1B in integumentary system disease                -Association score: 0.508836 -   Evidence for AMY1B in neoplasm of the thorax                            - Association score: 0.5086579             - Evidence for AMY1 in glandular cell neoplasm              - Association score: 0.50802636 The top three diseases:   Title: Salivary Alpha-Amylase Reactivity in Breast Cancer Survivors   Authors: Wan C, Couture-Lalande MÈ, Narain TA, Lebel S, Bielajew C   Summary of Abstract: This study looked at two primary components of the stress system which are the hypothalamic-pituitary-adrenal (HPA) and the sympathetic-adrenal-me...

 Hello, Today I explored the website interactome and STRING. While exploring these websites I searched up my assigned protein AMY1B and looked specifically at its different interactions. I first searched up AMY1B in interactomes database and in doing so, found that it interacted with the protein Mucin-7 or MUC7, which functions to promote the clearance of bacteria in the oral cavity. With that being said, I then searched up AMY1B on the website STRING, and it was here I found a series of different interactions with other proteins. Some of which were, H6PD, LCT, MGAM, and BPI just to name some.  After, looking at the two websites I found that they both had very different results. For instance, interactome had only one interaction listed while STRING had a total of eight interactions! However, out of those eight interactions, only four were determined experimentally whereas the other remaining four were from curated databases.  In closing, after exploring interactome and ST...