Bioinformatics - Assignment #1 (Week 1)

09/09/2020


Anthony Luna


Today I finished the first assignment of the bioinformatics project focusing on proteins. 


My assigned protein is Q5T084 AMY1B, also known as alpha-amylase 1B polypeptide (Reactome.org). It is found in Homo sapiens and aids in the bodily function of digestion and absorption. Specifically, digestion and absorption of branched starch, amylopectin, and linear starch, amylose (Reactome.org). All of which takes place in the extracellular region of various cells. Moving onto the size, mass, and structure of alpha-amylase 1B. The protein alpha-amylase is folded into three distinct domains, A, B, and C. Yet, my primary focus is on domain B, which has a length of 105 amino acids, aa, and a mass of 12.4 kilo Daltons, kDa (Proteinatlas.org). Alpha-amylase 1B is described as projecting off of domain A in a loop like fashion. However, when a calcium ion binds to domain B, it is then described as relatively rigid (Schutte). As for diseases involving alpha-amylase 1B, I’m still searching the literature to find out. I have not had any luck so far, although I did come across a study that noted how taking a patient’s salivary alpha-amylase measurement can be used to measure stress and anxiety. All in all, I am looking forward to expanding my knowledge of alpha-amylase 1B.  


References can be found in the comments below.

Comments

  1. Anthony LunaSeptember 9, 2020 at 9:29 PM

    AMY1B protein expression summary - The Human Protein Atlas. (n.d.). Proteinatlas.Org. https://www.proteinatlas.org/ENSG00000174876-AMY1B

    Reactome | AMY1B(16-511) [extracellular region]. (n.d.). Reactome.Org. https://reactome.org/content/detail/R-HSA-189001

    Schutte, S. (n.d.). Alpha_amylase. Virginia.Edu. https://collab.its.virginia.edu/access/content/group/f85bed6c-45d2-4b18-b868-6a2353586804/2/Ch07_Schutte_S_Alpha-Amylase_(Salivary)-_-/Ch07_Schutte_S_Alpha-Amylase_(Salivary)_Alpha_amylase.htm

    ReplyDelete
  2. KaylynnSeptember 10, 2020 at 6:58 PM

    This comment has been removed by the author.

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  3. KaylynnSeptember 10, 2020 at 6:59 PM

    Hello Anthony,

    Good job on gathering the information about your protein. There is a lot of information shown that could be presented in a more refined way.

    A list format might be easier to read the information.

    Example:

    Protein

    Size

    Weight

    Information about

    Where it is found

    Good first assignment. Keep up the good work.

    Chad

    ReplyDelete
  4. VUONG NGUYENSeptember 13, 2020 at 10:49 AM

    Hi Anthony,

    I believe you will get more knowledge from these assignment. I think the website is an amazing resource that we should discover more and more. I hope you will do well in your assignments and expand your knowledge as you want. Keep working hard and find out something that make you interesting.

    ReplyDelete

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